WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for the enriched GO category are listed in this table. For each GO category, the first row lists its sub-root (biological process, molecular function, or cellular component), category name, and corresponding GO ID.
The second row lists the following statistics:
Finally, genes in the category are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:biological process       Name:membrane fusion       ID:GO:0061025
C=87; O=2; E=0.22; R=9.09; rawP=0.0203; adjP=0.4943
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000183087 NA GAS6 growth arrest-specific 6 2621 ENSG00000183087
2  ENSG00000166900 NA STX3 syntaxin 3 6809 ENSG00000166900


Database:biological process       Name:carbohydrate derivative metabolic process       ID:GO:1901135
C=1211; O=7; E=3.06; R=2.29; rawP=0.0300; adjP=0.4943
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000064601 NA CTSA cathepsin A 5476 ENSG00000064601
2  ENSG00000174684 NA B3GNT1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 11041 ENSG00000174684
3  ENSG00000124155 NA PIGT phosphatidylinositol glycan anchor biosynthesis, class T 51604 ENSG00000124155
4  ENSG00000185236 NA RAB11B RAB11B, member RAS oncogene family 9230 ENSG00000185236
5  ENSG00000162736 NA NCSTN nicastrin 23385 ENSG00000162736
6  ENSG00000132394 NA EEFSEC eukaryotic elongation factor, selenocysteine-tRNA-specific 60678 ENSG00000132394
7  ENSG00000113161 NA HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 3156 ENSG00000113161


Database:biological process       Name:nervous system development       ID:GO:0007399
C=1724; O=11; E=4.36; R=2.52; rawP=0.0027; adjP=0.4943
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000166171 NA DPCD deleted in primary ciliary dyskinesia homolog (mouse) 25911 ENSG00000166171
2  ENSG00000105290 NA APLP1 amyloid beta (A4) precursor-like protein 1 333 ENSG00000105290
3  ENSG00000180739 NA S1PR5 sphingosine-1-phosphate receptor 5 53637 ENSG00000180739
4  ENSG00000124155 NA PIGT phosphatidylinositol glycan anchor biosynthesis, class T 51604 ENSG00000124155
5  ENSG00000162729 NA IGSF8 immunoglobulin superfamily, member 8 93185 ENSG00000162729
6  ENSG00000183087 NA GAS6 growth arrest-specific 6 2621 ENSG00000183087
7  ENSG00000144061 NA NPHP1 nephronophthisis 1 (juvenile) 4867 ENSG00000144061
8  ENSG00000166900 NA STX3 syntaxin 3 6809 ENSG00000166900
9  ENSG00000078808 NA SDF4 stromal cell derived factor 4 51150 ENSG00000078808
10  ENSG00000121753 NA BAI2 brain-specific angiogenesis inhibitor 2 576 ENSG00000121753
11  ENSG00000103260 NA METRN meteorin, glial cell differentiation regulator 79006 ENSG00000103260


Database:biological process       Name:response to light stimulus       ID:GO:0009416
C=203; O=3; E=0.51; R=5.84; rawP=0.0145; adjP=0.4943
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000144061 NA NPHP1 nephronophthisis 1 (juvenile) 4867 ENSG00000144061
2  ENSG00000078808 NA SDF4 stromal cell derived factor 4 51150 ENSG00000078808
3  ENSG00000113161 NA HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 3156 ENSG00000113161


Database:biological process       Name:system development       ID:GO:0048731
C=3521; O=15; E=8.90; R=1.68; rawP=0.0194; adjP=0.4943
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000166171 NA DPCD deleted in primary ciliary dyskinesia homolog (mouse) 25911 ENSG00000166171
2  ENSG00000105290 NA APLP1 amyloid beta (A4) precursor-like protein 1 333 ENSG00000105290
3  ENSG00000111913 NA FAM65B family with sequence similarity 65, member B 9750 ENSG00000111913
4  ENSG00000180739 NA S1PR5 sphingosine-1-phosphate receptor 5 53637 ENSG00000180739
5  ENSG00000124155 NA PIGT phosphatidylinositol glycan anchor biosynthesis, class T 51604 ENSG00000124155
6  ENSG00000109501 NA WFS1 Wolfram syndrome 1 (wolframin) 7466 ENSG00000109501
7  ENSG00000162729 NA IGSF8 immunoglobulin superfamily, member 8 93185 ENSG00000162729
8  ENSG00000183087 NA GAS6 growth arrest-specific 6 2621 ENSG00000183087
9  ENSG00000163703 NA CRELD1 cysteine-rich with EGF-like domains 1 78987 ENSG00000163703
10  ENSG00000144061 NA NPHP1 nephronophthisis 1 (juvenile) 4867 ENSG00000144061
11  ENSG00000166900 NA STX3 syntaxin 3 6809 ENSG00000166900
12  ENSG00000078808 NA SDF4 stromal cell derived factor 4 51150 ENSG00000078808
13  ENSG00000121753 NA BAI2 brain-specific angiogenesis inhibitor 2 576 ENSG00000121753
14  ENSG00000103260 NA METRN meteorin, glial cell differentiation regulator 79006 ENSG00000103260
15  ENSG00000113161 NA HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 3156 ENSG00000113161


Database:biological process       Name:cellular protein localization       ID:GO:0034613
C=931; O=6; E=2.35; R=2.55; rawP=0.0279; adjP=0.4943
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000064601 NA CTSA cathepsin A 5476 ENSG00000064601
2  ENSG00000183087 NA GAS6 growth arrest-specific 6 2621 ENSG00000183087
3  ENSG00000089248 NA ERP29 endoplasmic reticulum protein 29 10961 ENSG00000089248
4  ENSG00000144061 NA NPHP1 nephronophthisis 1 (juvenile) 4867 ENSG00000144061
5  ENSG00000109501 NA WFS1 Wolfram syndrome 1 (wolframin) 7466 ENSG00000109501
6  ENSG00000166900 NA STX3 syntaxin 3 6809 ENSG00000166900


Database:biological process       Name:extracellular matrix organization       ID:GO:0030198
C=211; O=3; E=0.53; R=5.62; rawP=0.0160; adjP=0.4943
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000105290 NA APLP1 amyloid beta (A4) precursor-like protein 1 333 ENSG00000105290
2  ENSG00000050767 NA COL23A1 collagen, type XXIII, alpha 1 91522 ENSG00000050767
3  ENSG00000183087 NA GAS6 growth arrest-specific 6 2621 ENSG00000183087


Database:biological process       Name:visual behavior       ID:GO:0007632
C=37; O=2; E=0.09; R=21.37; rawP=0.0039; adjP=0.4943
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000144061 NA NPHP1 nephronophthisis 1 (juvenile) 4867 ENSG00000144061
2  ENSG00000113161 NA HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 3156 ENSG00000113161


Database:biological process       Name:cell-type specific apoptotic process       ID:GO:0097285
C=261; O=3; E=0.66; R=4.54; rawP=0.0279; adjP=0.4943
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000183087 NA GAS6 growth arrest-specific 6 2621 ENSG00000183087
2  ENSG00000124155 NA PIGT phosphatidylinositol glycan anchor biosynthesis, class T 51604 ENSG00000124155
3  ENSG00000109501 NA WFS1 Wolfram syndrome 1 (wolframin) 7466 ENSG00000109501


Database:biological process       Name:single-organism reproductive behavior       ID:GO:0044704
C=70; O=2; E=0.18; R=11.30; rawP=0.0135; adjP=0.4943
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000144061 NA NPHP1 nephronophthisis 1 (juvenile) 4867 ENSG00000144061
2  ENSG00000113161 NA HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 3156 ENSG00000113161


Database:molecular function       Name:receptor regulator activity       ID:GO:0030545
C=44; O=2; E=0.10; R=19.30; rawP=0.0048; adjP=0.1088
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000163956 NA LRPAP1 low density lipoprotein receptor-related protein associated protein 1 4043 ENSG00000163956
2  ENSG00000183087 NA GAS6 growth arrest-specific 6 2621 ENSG00000183087


Database:molecular function       Name:calcium ion binding       ID:GO:0005509
C=668; O=6; E=1.57; R=3.81; rawP=0.0043; adjP=0.1088
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000130528 NA HRC histidine rich calcium binding protein 3270 ENSG00000130528
2  ENSG00000104805 NA NUCB1 nucleobindin 1 4924 ENSG00000104805
3  ENSG00000183087 NA GAS6 growth arrest-specific 6 2621 ENSG00000183087
4  ENSG00000163703 NA CRELD1 cysteine-rich with EGF-like domains 1 78987 ENSG00000163703
5  ENSG00000122359 NA ANXA11 annexin A11 311 ENSG00000122359
6  ENSG00000078808 NA SDF4 stromal cell derived factor 4 51150 ENSG00000078808


Database:molecular function       Name:heparin binding       ID:GO:0008201
C=131; O=3; E=0.31; R=9.72; rawP=0.0036; adjP=0.1088
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000105290 NA APLP1 amyloid beta (A4) precursor-like protein 1 333 ENSG00000105290
2  ENSG00000050767 NA COL23A1 collagen, type XXIII, alpha 1 91522 ENSG00000050767
3  ENSG00000163956 NA LRPAP1 low density lipoprotein receptor-related protein associated protein 1 4043 ENSG00000163956


Database:molecular function       Name:carboxylic acid binding       ID:GO:0031406
C=195; O=3; E=0.46; R=6.53; rawP=0.0107; adjP=0.1213
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000183087 NA GAS6 growth arrest-specific 6 2621 ENSG00000183087
2  ENSG00000166900 NA STX3 syntaxin 3 6809 ENSG00000166900
3  ENSG00000181396 NA C17orf101 chromosome 17 open reading frame 101 79701 ENSG00000181396


Database:molecular function       Name:glycosaminoglycan binding       ID:GO:0005539
C=174; O=3; E=0.41; R=7.32; rawP=0.0079; adjP=0.1213
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000105290 NA APLP1 amyloid beta (A4) precursor-like protein 1 333 ENSG00000105290
2  ENSG00000050767 NA COL23A1 collagen, type XXIII, alpha 1 91522 ENSG00000050767
3  ENSG00000163956 NA LRPAP1 low density lipoprotein receptor-related protein associated protein 1 4043 ENSG00000163956


Database:molecular function       Name:carbohydrate derivative binding       ID:GO:0097367
C=189; O=3; E=0.45; R=6.74; rawP=0.0098; adjP=0.1213
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000105290 NA APLP1 amyloid beta (A4) precursor-like protein 1 333 ENSG00000105290
2  ENSG00000050767 NA COL23A1 collagen, type XXIII, alpha 1 91522 ENSG00000050767
3  ENSG00000163956 NA LRPAP1 low density lipoprotein receptor-related protein associated protein 1 4043 ENSG00000163956


Database:molecular function       Name:anion binding       ID:GO:0043168
C=2402; O=11; E=5.66; R=1.94; rawP=0.0189; adjP=0.1836
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000128581 NA RABL5 RAB, member RAS oncogene family-like 5 64792 ENSG00000128581
2  ENSG00000105290 NA APLP1 amyloid beta (A4) precursor-like protein 1 333 ENSG00000105290
3  ENSG00000050767 NA COL23A1 collagen, type XXIII, alpha 1 91522 ENSG00000050767
4  ENSG00000163956 NA LRPAP1 low density lipoprotein receptor-related protein associated protein 1 4043 ENSG00000163956
5  ENSG00000185236 NA RAB11B RAB11B, member RAS oncogene family 9230 ENSG00000185236
6  ENSG00000132394 NA EEFSEC eukaryotic elongation factor, selenocysteine-tRNA-specific 60678 ENSG00000132394
7  ENSG00000071553 NA ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 537 ENSG00000071553
8  ENSG00000183087 NA GAS6 growth arrest-specific 6 2621 ENSG00000183087
9  ENSG00000166900 NA STX3 syntaxin 3 6809 ENSG00000166900
10  ENSG00000181396 NA C17orf101 chromosome 17 open reading frame 101 79701 ENSG00000181396
11  ENSG00000113161 NA HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 3156 ENSG00000113161


Database:molecular function       Name:guanyl nucleotide binding       ID:GO:0019001
C=392; O=3; E=0.92; R=3.25; rawP=0.0641; adjP=0.4359
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000128581 NA RABL5 RAB, member RAS oncogene family-like 5 64792 ENSG00000128581
2  ENSG00000185236 NA RAB11B RAB11B, member RAS oncogene family 9230 ENSG00000185236
3  ENSG00000132394 NA EEFSEC eukaryotic elongation factor, selenocysteine-tRNA-specific 60678 ENSG00000132394


Database:molecular function       Name:guanyl ribonucleotide binding       ID:GO:0032561
C=392; O=3; E=0.92; R=3.25; rawP=0.0641; adjP=0.4359
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000128581 NA RABL5 RAB, member RAS oncogene family-like 5 64792 ENSG00000128581
2  ENSG00000185236 NA RAB11B RAB11B, member RAS oncogene family 9230 ENSG00000185236
3  ENSG00000132394 NA EEFSEC eukaryotic elongation factor, selenocysteine-tRNA-specific 60678 ENSG00000132394


Database:molecular function       Name:GTP binding       ID:GO:0005525
C=379; O=3; E=0.89; R=3.36; rawP=0.0592; adjP=0.4359
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000128581 NA RABL5 RAB, member RAS oncogene family-like 5 64792 ENSG00000128581
2  ENSG00000185236 NA RAB11B RAB11B, member RAS oncogene family 9230 ENSG00000185236
3  ENSG00000132394 NA EEFSEC eukaryotic elongation factor, selenocysteine-tRNA-specific 60678 ENSG00000132394


Database:cellular component       Name:endoplasmic reticulum part       ID:GO:0044432
C=919; O=10; E=2.32; R=4.32; rawP=7.41e-05; adjP=0.0016
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000130528 NA HRC histidine rich calcium binding protein 3270 ENSG00000130528
2  ENSG00000050767 NA COL23A1 collagen, type XXIII, alpha 1 91522 ENSG00000050767
3  ENSG00000163956 NA LRPAP1 low density lipoprotein receptor-related protein associated protein 1 4043 ENSG00000163956
4  ENSG00000124155 NA PIGT phosphatidylinositol glycan anchor biosynthesis, class T 51604 ENSG00000124155
5  ENSG00000109501 NA WFS1 Wolfram syndrome 1 (wolframin) 7466 ENSG00000109501
6  ENSG00000125991 NA ERGIC3 ERGIC and golgi 3 51614 ENSG00000125991
7  ENSG00000183087 NA GAS6 growth arrest-specific 6 2621 ENSG00000183087
8  ENSG00000089248 NA ERP29 endoplasmic reticulum protein 29 10961 ENSG00000089248
9  ENSG00000161671 NA EMC10 ER membrane protein complex subunit 10 284361 ENSG00000161671
10  ENSG00000113161 NA HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 3156 ENSG00000113161


Database:cellular component       Name:endoplasmic reticulum lumen       ID:GO:0005788
C=170; O=5; E=0.43; R=11.66; rawP=6.58e-05; adjP=0.0016
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000130528 NA HRC histidine rich calcium binding protein 3270 ENSG00000130528
2  ENSG00000050767 NA COL23A1 collagen, type XXIII, alpha 1 91522 ENSG00000050767
3  ENSG00000163956 NA LRPAP1 low density lipoprotein receptor-related protein associated protein 1 4043 ENSG00000163956
4  ENSG00000183087 NA GAS6 growth arrest-specific 6 2621 ENSG00000183087
5  ENSG00000089248 NA ERP29 endoplasmic reticulum protein 29 10961 ENSG00000089248


Database:cellular component       Name:endoplasmic reticulum       ID:GO:0005783
C=1282; O=12; E=3.23; R=3.71; rawP=5.31e-05; adjP=0.0016
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000130528 NA HRC histidine rich calcium binding protein 3270 ENSG00000130528
2  ENSG00000050767 NA COL23A1 collagen, type XXIII, alpha 1 91522 ENSG00000050767
3  ENSG00000163956 NA LRPAP1 low density lipoprotein receptor-related protein associated protein 1 4043 ENSG00000163956
4  ENSG00000124155 NA PIGT phosphatidylinositol glycan anchor biosynthesis, class T 51604 ENSG00000124155
5  ENSG00000109501 NA WFS1 Wolfram syndrome 1 (wolframin) 7466 ENSG00000109501
6  ENSG00000125991 NA ERGIC3 ERGIC and golgi 3 51614 ENSG00000125991
7  ENSG00000064601 NA CTSA cathepsin A 5476 ENSG00000064601
8  ENSG00000183087 NA GAS6 growth arrest-specific 6 2621 ENSG00000183087
9  ENSG00000089248 NA ERP29 endoplasmic reticulum protein 29 10961 ENSG00000089248
10  ENSG00000162736 NA NCSTN nicastrin 23385 ENSG00000162736
11  ENSG00000161671 NA EMC10 ER membrane protein complex subunit 10 284361 ENSG00000161671
12  ENSG00000113161 NA HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 3156 ENSG00000113161


Database:cellular component       Name:azurophil granule       ID:GO:0042582
C=7; O=2; E=0.02; R=113.31; rawP=0.0001; adjP=0.0016
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000122359 NA ANXA11 annexin A11 311 ENSG00000122359
2  ENSG00000166900 NA STX3 syntaxin 3 6809 ENSG00000166900


Database:cellular component       Name:primary lysosome       ID:GO:0005766
C=7; O=2; E=0.02; R=113.31; rawP=0.0001; adjP=0.0016
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000122359 NA ANXA11 annexin A11 311 ENSG00000122359
2  ENSG00000166900 NA STX3 syntaxin 3 6809 ENSG00000166900


Database:cellular component       Name:specific granule       ID:GO:0042581
C=9; O=2; E=0.02; R=88.13; rawP=0.0002; adjP=0.0027
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000122359 NA ANXA11 annexin A11 311 ENSG00000122359
2  ENSG00000166900 NA STX3 syntaxin 3 6809 ENSG00000166900


Database:cellular component       Name:pigment granule       ID:GO:0048770
C=94; O=3; E=0.24; R=12.66; rawP=0.0017; adjP=0.0162
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000089248 NA ERP29 endoplasmic reticulum protein 29 10961 ENSG00000089248
2  ENSG00000162736 NA NCSTN nicastrin 23385 ENSG00000162736
3  ENSG00000122359 NA ANXA11 annexin A11 311 ENSG00000122359


Database:cellular component       Name:integral to organelle membrane       ID:GO:0031301
C=208; O=4; E=0.52; R=7.63; rawP=0.0018; adjP=0.0162
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000174684 NA B3GNT1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 11041 ENSG00000174684
2  ENSG00000124155 NA PIGT phosphatidylinositol glycan anchor biosynthesis, class T 51604 ENSG00000124155
3  ENSG00000109501 NA WFS1 Wolfram syndrome 1 (wolframin) 7466 ENSG00000109501
4  ENSG00000161671 NA EMC10 ER membrane protein complex subunit 10 284361 ENSG00000161671


Database:cellular component       Name:melanosome       ID:GO:0042470
C=94; O=3; E=0.24; R=12.66; rawP=0.0017; adjP=0.0162
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000089248 NA ERP29 endoplasmic reticulum protein 29 10961 ENSG00000089248
2  ENSG00000162736 NA NCSTN nicastrin 23385 ENSG00000162736
3  ENSG00000122359 NA ANXA11 annexin A11 311 ENSG00000122359


Database:cellular component       Name:intrinsic to organelle membrane       ID:GO:0031300
C=230; O=4; E=0.58; R=6.90; rawP=0.0026; adjP=0.0175
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000174684 NA B3GNT1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 11041 ENSG00000174684
2  ENSG00000124155 NA PIGT phosphatidylinositol glycan anchor biosynthesis, class T 51604 ENSG00000124155
3  ENSG00000109501 NA WFS1 Wolfram syndrome 1 (wolframin) 7466 ENSG00000109501
4  ENSG00000161671 NA EMC10 ER membrane protein complex subunit 10 284361 ENSG00000161671




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).